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Test Code HMGES 3-Hydroxy-3-Methylglutaryl Coenzyme-A (HMG-CoA) Reductase, ELISA, Serum

Reporting Name

HMG-CoA ELISA, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Evaluating patients with suspected necrotizing autoimmune myopathy

 

Measuring 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)


Advisory Information


NMS1 / Necrotizing Myopathy Evaluation, Serum is the preferred first tier test for identification of antibodies specific for necrotizing autoimmune myopathy (HMGCOA-IgG and SRP-IgG). This initial screen includes signal recognition particle (SRP) antibodies performed using tissue indirect immunofluorescence, which increases the clinical sensitivity as compared to SRP immunoblot methodologies.



Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 2 mL


Specimen Type

Serum

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

<20.0 U/mL

Day(s) and Time(s) Performed

Tuesday, Friday; 6 a.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83516

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HMGES HMG-CoA ELISA, S 93493-5

 

Result ID Test Result Name Result LOINC Value
603538 HMG-CoA ELISA, S 93493-5