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Test Code LYZZ Lysozyme (LYZ) Gene, Full Gene Analysis, Varies

Reporting Name

LYZ Gene, Full Gene Analysis

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Confirming a diagnosis of lysozyme (LYZ) gene-related familial visceral amyloidosis


This test is not useful for assessment of lysozyme levels.

Method Name

Polymerase Chain Reaction (PCR) followed by DNA Sequencing

Advisory Information

This test does not provide enzyme activity levels. For lysozyme enzyme activity, order MUR / Lysozyme (Muramidase), Plasma.

Shipping Instructions

Specimen preferred to arrive within 96 hours of collection.

Specimen Required

Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.

Specimen Type: Whole blood


Preferred: Lavender top (EDTA) or yellow top (ACD)

Acceptable: Any anticoagulant

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.

Specimen Type


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

An interpretive report will be provided.


All detected alterations are evaluated according to American College of Medical Genetics and Genomics (ACMG) recommendations.(1) Variants are classified based on known, predicted, or possible pathogenicity and reported with interpretive comments detailing their potential or known significance.

Day(s) and Time(s) Performed

Weekly; Varies

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81479-Unlisted molecular pathology procedure

LOINC Code Information

Test ID Test Order Name Order LOINC Value
LYZZ LYZ Gene, Full Gene Analysis 94205-2


Result ID Test Result Name Result LOINC Value
53078 Result Summary 50397-9
53079 Result 82939-0
53080 Interpretation 69047-9
53081 Additional Information 48767-8
53082 Specimen 31208-2
53083 Source 31208-2
53084 Released By 18771-6


1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available in Special Instructions:

-Informed Consent for Genetic Testing (T576)

-Informed Consent for Genetic Testing-Spanish (T826)

2. Molecular Genetics: Congenital Inherited Diseases Patient Information (T521) in Special Instructions

3. If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.