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HelpTest Code ALDNA Aldosterone with Sodium, 24 Hour, Urine
Reporting Name
Aldosterone with Sodium, UrinePerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Investigating primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (eg, renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome) in conjunction with urine sodium levels
Method Name
ALDU: Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
NAU: Potentiometric, Indirect Ion-Selective Electrode (ISE)
Necessary Information
24-Hour volume (in milliliters) is required.
Specimen Required
Patient Preparation: Spironolactone (Aldactone) should be discontinued for 4 to 6 weeks before testing. The plasma renin activity cannot be interpreted if the patient is being treated with spironolactone.
Supplies: Sarstedt Aliquot Tube 5mL (T914)
Container/Tube: 2 Plastic, 5-mL tubes
Specimen Volume: 10 mL
Collection Instructions:
1. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children under the age of 5 years. This preservative is intended to achieve a pH of between approximately 2 and 4.
2. Collect urine for a full 24 hours (required) and record the total volume.
3. Place 5 mL of well mixed, 24-hour urine in plastic, 5-mL tube and label as Aldosterone.
4. Place 5 mL of well mixed, 24-hour urine in plastic, 5-mL tube and label as Sodium.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
Specimen Type
UrineSpecimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days | ||
| Ambient | 7 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
ALDOSTERONE
0-30 days: 0.7-11.0 mcg/24 h*
1-11 months: 0.7-22.0 mcg/24 h*
≥1 year: 2.0-20.0 mcg/24 h
*Loeuille GA, Racadot A, Vasseur P, Vandewalle B. Blood and urinary aldosterone levels in normal neonates, infants and children. Pediatrie 1981;36(5):335-344
SODIUM
41-227 mmol/24 h
If the 24-hour urinary sodium excretion is greater than 200 mmol, the urinary aldosterone excretion should be less than10 mcg.
Interpretation
Under normal circumstances, if the 24-hour urinary sodium excretion is greater than 200 mmol, the urinary aldosterone excretion should be less than 10 mcg/24 hours.
Urinary aldosterone excretion greater than 12 mcg/24 hours as part of an aldosterone suppression test is consistent with hyperaldosteronism.
Twenty-four-hour urinary sodium excretion should exceed 200 mmol to document adequate sodium repletion.
For more information see Renin-Aldosterone Studies
Note: Advice on stimulation or suppression tests is available from Mayo Clinic's Division of Endocrinology; call 800-533-1710.
Day(s) Performed
Tuesday, Thursday
Report Available
2 to 8 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82088-Aldosterone
84300-Sodium
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ALDNA | Aldosterone with Sodium, Urine | 94871-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| NA_24 | Sodium, 24 HR, U | 2956-1 |
| 8556 | Aldosterone, U | 1765-7 |
| TM47 | Collection Duration (h) | 13362-9 |
| TM11 | Collection Duration | 13362-9 |
| VL9 | Urine Volume | 3167-4 |
| VL45 | Volume (mL) | 3167-4 |
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ALDU | Aldosterone, U | Yes | Yes |
| NAU | Sodium, 24 HR, U | Yes | Yes |