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Accreditations

Specimen Collection

Additional Information

Specimen Collection and Transportation from Billings Clinic Main Campus

Specimen Collection and Transportation from Regional and Reference Clients

 

Mayo Clinic Laboratories

Test Code Billings Clinic: 4355 Vancomycin, Trough, Plasma or Serum

Important Note

This test can not be added on to a specimen that is already in the lab.  A new sample must be drawn.

Performing Laboratory

Billings Clinic Laboratory: Chemistry

Useful For

Trough concentrations drawn at steady-state are the preferred test for monitoring vancomycin therapy

Methodology

Particle-enhance turbidimetric inhibition immunoassay (PETINIA)

Specimen Requirements

Submit only 1 of the following specimens:

Serum or plasma should be physically separated from cells as soon as possible with a maximum limit of two hours from the time of collection.

 

Plasma

  • Draw blood in a green-top (lithium heparin) tube(s).
  • Spin down and send 1.0 mL of heparinized plasma frozen.
  • Plasma for a trough level is usually drawn just prior to next dose,
  • Date and time of last dose are required on request form for processing.

 

Serum

  • Draw blood in a plain, red-top tube(s) or a serum gel tube(s).
  • Spin down and send 1.0 mL of serum frozen
  • Serum for a trough level is usually drawn just prior to next dose,
  • Date and time of last dose are required on request form for processing.

Storage/Stability

Specimen Type Temperature Time
Plasma, Serum Refrigerated 2 days
  Frozen (preferred) 1 month
  Ambient 8 hours

 

Reference Values

Therapeutic concentration:  10.0 - 20.0 µg/mL

Skin and Soft Tissue, UTI: 10.0 - 15.0 ug/mL

Bacteremia, Endocarditis, Febrile Neutropenia, Pneumonia, Osteomyelitis, Meningitis: 15.0 - 20.0 ug/mL

 

Call back concentration:  < 5.0 or > 20.0  µg/mL

Day(s) Test Set Up

Daily

Test Classification and CPT Coding

80202 - Vancomycin

LOINC Code Information

Reporting Name LOINC Code
Vancomycin, Trough 4092-3

 

Interferences

  • Vancomycin crystalline degradation product (CDP‑1) at 20 µg/mL CDP‑1 demonstrates crossreactivity at 0 and 10 µg/mL vancomycin of 21.0% and 19.1% respectively.