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HelpTest Code Billings Clinic: 7083 Autoantibodies to Scl-70, IgG, Serum
Additional Codes
| Ordering Mnemonic |
|---|
| MayoAccess: BCL397 |
Performing Laboratory
Billings Clinic Laboratory: Immunology
Useful For
- Useful for evaluation of patients suspected of having systemic scleroderma (SS).
- Anti-Scl-70 antibodies are found in 20-40% of SSc patients and in up to 70% of patients with diffuse cutaneous SSc and they are associated with severe disease progression.
- Although reported in other pathologies, especially in systemic lupus erythematosus (SLE), anti-Scl-70 antibodies are a useful marker for the diagnosis of SSc.
Methodology
Chemiluminescent immunoassay
Specimen Requirements
- Draw blood in a serum gel tube(s).
- Spin down and send 0.5 mL (pediatric: 0.2 mL) of serum frozen in plastic vial.
Storage/Stability
| Specimen Type | Temperature | Time |
| Serum | Refrigerated | 14 days |
| Frozen (preferred) | 1 year | |
| Ambient (spun) | 48 hours |
Reject Due To
- Microbial contamination
- Heat-treated specimens
- >3 freeze/thaw cycles
- Specimen other than serum
Reference Values
<20 CU (Chemiluminescent Units)
Interpretive Remark: The following results were obtained with the INOVA QUANTA Flash Scl-70 Chemiluminescent immunoassay. Values obtained with different manufacturers' assay methods may not be used interchangeably.
Day(s) Test Set Up
Tuesday, Thursday
Test Classification and CPT Coding
86235 - Extractable nuclear antigen, antibody to, any method, each antibody
LOINC Code Information
| Reporting Name | LOINC Code |
| Anti-Scl-70, IgG | 47322-3 |