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HelpTest Code DCORT 11-Deoxycortisol, Serum
Reporting Name
11-Deoxycortisol, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Diagnostic workup of patients with congenital adrenal hyperplasia
Part of metyrapone testing in the workup of suspected secondary or tertiary adrenal insufficiency
Part of metyrapone testing in the differential diagnostic workup of Cushing syndrome
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Necessary Information
Indicate if specimen was collection before or after metyrapone administration.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Morning (8 a.m.) specimen is preferred.
2. Centrifuge and aliquot serum into a plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
≤18 years: <344 ng/dL
>18 years: 10-79 ng/dL
For International System of Units (SI) conversion for Reference Values, see www.mayocliniclabs.com/order-tests/si-unit-conversion.html.
Interpretation
In a patient suspected of having congenital adrenal hyperplasia (CAH), elevated serum 11-deoxycortisol levels indicate possible 11-beta-hydroxylase deficiency. However, not all patients will show baseline elevations in serum 11-deoxycortisol levels. In a significant proportion of cases, increases in 11-deoxycortisol levels are only apparent after corticotropin (previously adrenocorticotropic hormone)(1-24) stimulation.(1)
Serum 11-deoxycortisol levels below 1700 ng/dL when measured 8 hours after metyrapone administration is indicative of probable adrenal insufficiency. The test cannot reliably distinguish between primary and secondary or tertiary causes of adrenal failure, as neither patients with pituitary failure, nor those with primary adrenocortical failure, tend to show an increase of 11-deoxycortisol levels after metyrapone is administered.
For more information see Steroid Pathways.
Day(s) Performed
Tuesday
Report Available
3 to 10 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82634
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| DCORT | 11-Deoxycortisol, S | 1657-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 46923 | 11-Deoxycortisol, S | 1657-6 |
Testing Algorithm
For more information see Steroid Pathways.