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Test Code OXYSX Oxycodone Screen, Chain of Custody, Random, Urine

Reporting Name

Oxycodone Screen, CoC, U

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Detection of oxycodone and oxymorphone in urine following chain-of-custody procedures


This chain-of-custody test is intended to be used in a setting where the test results can be used definitively to make a diagnosis.

Method Name


Specimen Required

Container/Tube: Chain-of-Custody Kit (T282) containing the specimen containers, seals, and documentation required.

Specimen Volume: 20 mL

Collection Instructions: Collect specimen in the container provided, seal, and submit with the associated documentation to satisfy the legal requirements for chain-of-custody testing.

Specimen Type


Specimen Minimum Volume

2.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values


Screening cutoff concentration:

Oxycodone: 100 ng/mL


A positive result indicates that the patient has used the drugs detected in the recent past. See individual tests (eg, OXYCU / Oxycodone with Metabolite Confirmation, Urine) for more information.


For information about drug testing, including estimated detection times, see Drugs of Abuse Testing.

Day(s) and Time(s) Performed

Monday through Friday

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
OXYSX Oxycodone Screen, CoC, U 19642-8


Result ID Test Result Name Result LOINC Value
61727 Oxycodone 19642-8
36027 Chain of Custody 77202-0

Additional Tests

Test ID Reporting Name Available Separately Always Performed
COCH Chain of Custody Processing No Yes
ADLTX Adulterants Survey, CoC, U Yes Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
OXYCX Oxycodone w/metabolite Conf, CoC, U Yes No

Testing Algorithm

Testing begins with screening assay. If oxycodone screen is positive, then the liquid chromatography-tandem mass spectrometry (LC-MS/MS) confirmation with quantification will be performed at an additional charge.


Adulterants testing will be performed on all chain of custody urine samples as per regulatory requirements.


1. Chain-of-Custody Request is included in the Chain-of-Custody Kit (T282).

2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.