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HelpTest Code RAPAN Rheumatoid Arthritis Panel, Serum
Ordering Guidance
This test is the optimal first-line antibody panel for evaluating patients at-risk for rheumatoid arthritis.
The following testing may also be useful:
ENAE / Antibody to Extractable Nuclear Antigen Evaluation, Serum
ADNA1 / Double-Stranded DNA (dsDNA) Antibodies , IgG, Serum
NAIFA / Antinuclear Antibodies, HEp-2 Substrate, IgG, Serum
CTDC / Connective Tissue Diseases Cascade, Serum
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Evaluating patients suspected of having rheumatoid arthritis (RA)
Differentiating RA from other inflammatory arthritis or connective tissue diseases
Diagnosis and stratification of rheumatoid arthritis
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CCP | Cyclic Citrullinated Peptide Ab, S | Yes | Yes |
| RHUT | Rheumatoid Factor, S | Yes | Yes |
Special Instructions
Method Name
CCP: Enzyme-Linked Immunosorbent Assay (ELISA)
RHUT: Turbidimetry
Reporting Name
Rheumatoid Arthritis Panel, SSpecimen Type
SerumSpecimen Minimum Volume
1.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
| Heat-treated specimen | Reject |
Reference Values
Cyclic Citrullinated Peptide Antibodies, IgG
<20.0 U (negative)
20.0-39.9 U (weak positive)
40.0-59.9 U (positive)
≥60.0 U (strong positive)
Reference values apply to all ages.
Rheumatoid Factor
<15 IU/mL
Interpretation
Cyclic Citrullinated Peptide Antibodies:
A positive result for cyclic citrullinated peptide (CCP) antibodies may be suggestive of rheumatoid arthritis (RA) if compatible clinical features of disease are present.
Significantly elevated levels of CCP antibodies may be useful to identify RA patients with erosive joint disease.
A Mayo Clinic prospective clinical evaluation of the CCP antibody test showed a diagnostic sensitivity for RA of 78% with fewer than 5% false-positive results in healthy controls (see Cautions).
Rheumatoid Factor:
Positive results may be suggestive of RA if compatible clinical features of disease are present.
Day(s) Performed
Monday through Saturday
Report Available
2 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86200
86431
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| RAPAN | Rheumatoid Arthritis Panel, S | 46437-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CCP | Cyclic Citrullinated Peptide Ab, S | 33935-8 |
| RHUT | Rheumatoid Factor, S | 11572-5 |
Forms
If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.