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Test Code ROC Rubeola (Measles) Antibodies, IgG and IgM, Spinal Fluid

Reporting Name

Rubeola (Measles) Ab, IgG,IgM, CSF

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Diagnosing central nervous system rubeola (measles) virus infection and/or subacute sclerosing panencephalitis

Method Name

Immunofluorescence Assay (IFA)


Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 0.25 mL


Specimen Type

CSF

Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 14 days
  Frozen  14 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK

Reference Values

IgG: <1:5

IgM: <1:10

Reference values apply to all ages.

Interpretation

Detection of organism-specific antibodies in the cerebrospinal fluid (CSF) may suggest central nervous system infection. However, these results are unable to distinguish between intrathecal antibodies and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. The results should be interpreted with other laboratory and clinical data prior to a diagnosis of central nervous system infection.

 

Patients with subacute sclerosing panencephalitis have serum antibody titers that are 10 to 100 times higher than those seen in late convalescent-phase sera. More importantly, there is pronounced local production of oligoclonal measles virus antibodies in the central nervous system.

Day(s) Performed

Monday through Friday

Report Available

1 to 4 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86765 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ROC Rubeola (Measles) Ab, IgG,IgM, CSF 90254-4

 

Result ID Test Result Name Result LOINC Value
5741 Rubeola (Measles) Ab, IgG 22501-1
5742 Rubeola (Measles) Ab, IgM In Process

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.