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HelpTest Code 2B6Q Cytochrome P450 2B6 Genotype, Varies
Reporting Name
CYP2B6 Genotype, VPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Aiding in determining therapeutic strategies for drugs that are metabolized by cytochrome P450 (CYP) 2B6
Providing information relevant to bupropion, efavirenz, ketamine, methadone, and nevirapine, as well as other medications metabolized by CYP2B6
Determining the genotype if genotype-phenotype discord is encountered clinically after testing with a less comprehensive genotyping method has occurred
Identifying genotype when required for drug trials and research protocols
Method Name
Real Time-Polymerase Chain Reaction (RT-PCR) with Allelic Discrimination Analysis
Ordering Guidance
Testing is available as the single gene assay (this test) and as a part of a psychotropic pharmacogenomics panel.
If genotype testing for psychotropic medications is requested, order PSYQP / Psychotropic Pharmacogenomics Gene Panel, Varies.
Specimen Required
Submit only 1 of the following specimens:
Specimen Type: Whole blood
Container/Tube: Lavender top (EDTA)
Specimen Volume: 3 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send whole blood specimen in original tube. Do not aliquot.
Specimen Stability Information: Ambient (preferred) 9 days/Refrigerated 30 days
Specimen Type: Saliva
Patient Preparation: Patient should not eat, drink, smoke, or chew gum 30 minutes prior to collection.
Supplies: Saliva Swab Collection Kit (T786)
Specimen Volume: 1 Swab
Collection Instructions: Collect and send specimen per kit instructions.
Specimen Stability Information: Ambient 30 days
Specimen Type: Extracted DNA
Container/Tube: 2 mL screw top tube
Specimen Volume: 100 mcL (microliters)
Collection Instructions:
1. The preferred volume is 100 mcL at a concentration of 50 ng/mcL.
2. Provide concentration of DNA and volume on tube.
Specimen Stability Information: Frozen (preferred) 1 year/Ambient/Refrigerated
Specimen Type
VariesSpecimen Minimum Volume
Blood: 1 mL
Saliva, extracted DNA: see Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Varies | ||
Reject Due To
| All specimens will be evaluated at Mayo Clinic Laboratories for test suitability. |
Reference Values
An interpretive report will be provided.
Interpretation
An interpretive report will be provided.
The genotype, with associated star alleles, is assigned using standard allelic nomenclature as published by the Pharmacogene Variation (PharmVar) Consortium.(1)
For additional information regarding pharmacogenomic genes and their associated drugs, see Pharmacogenomic Associations Tables. This resource also includes information regarding enzyme inhibitors and inducers, as well as potential alternate drug choices.
Day(s) Performed
Monday through Friday
Report Available
3 to 8 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
81479
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| 2B6Q | CYP2B6 Genotype, V | 72511-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 610082 | CYP2B6 Genotype | 72882-4 |
| 610083 | CYP2B6 Phenotype | 79720-9 |
| 610566 | CYP2B6 Activity Score | 104666-3 |
| 610084 | Interpretation | 69047-9 |
| 610085 | Additional Information | 48767-8 |
| 610086 | Method | 85069-3 |
| 610087 | Disclaimer | 62364-5 |
| 610088 | Reviewed by | 18771-6 |
Forms
1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available:
-Informed Consent for Genetic Testing (T576)
-Informed Consent for Genetic Testing-Spanish (T826)
2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.