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HelpTest Code AIHL Aminoglycoside-Induced Hearing Loss, Targeted Variant Testing, Droplet Digital PCR, Varies
Reporting Name
Aminoglycoside-Induced Hearing LossPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Identification of individuals who may be at risk for aminoglycoside-induced hearing loss (AIHL)
Establishing a diagnosis of late-onset sensorineural hearing loss associated with aminoglycoside exposure
Identifying mitochondrial variants associated with AIHL, allowing for predictive testing of at-risk family members
Method Name
Droplet Digital Polymerase Chain Reaction (ddPCR)
Ordering Guidance
The preferred genetic test for diagnosis in individuals with suspicion of syndromic or non-syndromic hereditary hearing loss is HHLP / AudioloGene Hereditary Hearing Loss Panel, Varies.
Shipping Instructions
Specimen preferred to arrive within 96 hours of collection.
Specimen Required
Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.
Specimen Type: Whole blood
Container/Tube:
Preferred: Lavender top (EDTA) or yellow top (ACD)
Acceptable: Any anticoagulant
Specimen Volume: 3 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send specimen in original tube.
Specimen Stability Information: Ambient/Refrigerated/Frozen
Additional Information: To ensure minimum volume and concentration of DNA is met, the preferred volume of blood must be submitted. Testing may be canceled if DNA requirements are inadequate.
Specimen Type: Saliva
Patient Preparation: Patient should not eat, drink, smoke, or chew gum 30 minutes prior to collection.
Supplies: Saliva Collection Kit (T786)
Specimen Volume: 1 swab
Collection Instructions: Collect and send specimen per kit instructions.
Specimen Stability Information: Ambient
Specimen Type
VariesSpecimen Minimum Volume
See Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Varies | ||
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
An interpretive report will be provided.
Interpretation
An interpretive report will be provided.
Day(s) Performed
Monday through Saturday
Report Available
1 to 7 days-Specimens must arrive in the performing laboratory by 12 p.m. for the report to be available 1 day from specimen receipt.Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
81401
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| AIHL | Aminoglycoside-Induced Hearing Loss | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 609786 | Specimen | 31208-2 |
| 609787 | Source | 31208-2 |
| 609788 | Result Summary | 50397-9 |
| 609789 | Result | 82939-0 |
| 609790 | Interpretation | 69047-9 |
| 609791 | Additional Information | 48767-8 |
| 609792 | Method | 85069-3 |
| 609793 | Disclaimer | 62364-5 |
| 609794 | Released By | 18771-6 |
Forms
1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available:
-Informed Consent for Genetic Testing (T576)
-Informed Consent for Genetic Testing (Spanish) (T826)
2. Molecular Genetics Hereditary Hearing Loss Patient Information3. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.