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HelpTest Code APGAL Galactose-Alpha-1,3-Galactose (Alpha-Gal) Mammalian Meat Allergy Profile, Serum
Reporting Name
Alpha-Gal Panel, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
As an aid in diagnosis of an IgE mediated hypersensitivity allergy to non-primate mammalian red meat, such as beef, pork, venison, and meat-derived products, such as gelatin, via allergen profile testing
This test is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists.
This test is not useful for patients in whom the medical management does not depend upon identification of allergen specificity.
Method Name
Fluorescence Enzyme Immunoassay (FEIA)
Ordering Guidance
For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies.
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
Reference Values
|
Class |
IgE kU/L |
Interpretation |
|
0 |
<0.10 |
Negative |
|
0/1 |
0.10-0.34 |
Borderline/equivocal |
|
1 |
0.35-0.69 |
Equivocal |
|
2 |
0.70-3.49 |
Positive |
|
3 |
3.50-17.4 |
Positive |
|
4 |
17.5-49.9 |
Strongly positive |
|
5 |
50.0-99.9 |
Strongly positive |
|
6 |
≥100 |
Strongly positive |
Concentrations of 0.70 Ku/L or more (class 2 and above) will flag as abnormally high
Reference values apply to all ages.
Interpretation
Detection of IgE antibodies in serum (class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be responsible for eliciting signs and symptoms.
The level of IgE antibodies in serum varies directly with the concentration of IgE antibodies expressed as a class score or kU/L.
Day(s) Performed
Monday through Friday
Report Available
Same day/1 to 3 daysTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86003 x 4
86008
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| APGAL | Alpha-Gal Panel, S | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| BEEF | Beef, IgE | 6039-2 |
| LAMB | Lamb, IgE | 6155-6 |
| MILK | Milk, IgE | 6174-7 |
| PORK | Pork, IgE | 6219-0 |
| ALGAL | Galactose-alpha-1,3-galactose, IgE | 73837-7 |
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Allergen Test Request (T236)
-Microbiology Test Request (T244)
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ALGAL | Galactose-alpha-1,3-galactose, IgE | Yes | Yes |
| BEEF | Beef, IgE | Yes | Yes |
| PORK | Pork, IgE | Yes | Yes |
| LAMB | Lamb, IgE | Yes | Yes |
| MILK | Milk, IgE | Yes | Yes |
Testing Algorithm
Other meat allergen IgE antibody tests may be considered in addition to galactose-alpha-1,3-galactose IgE antibody testing in cases of suspected red meat allergy.