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HelpTest Code APOEG Apolipoprotein E Genotyping, Blood
Reporting Name
Apolipoprotein E Genotyping, BPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Determining the specific apolipoprotein E (APOE) genotypes in individuals with type III hyperlipoproteinemia
Determining the specific apolipoprotein E (APOE) genotypes that may increase risk for amyloid related imaging abnormalities in individuals being treated for Alzheimer disease with B-amyloid-targeting antibodies
APOE genotyping has been used to assess susceptibility for Alzheimer disease. However, the use of APOE analysis for predictive testing for Alzheimer disease is not currently recommended by the American College of Medical Genetics due to limited clinical utility and poor predictive value.
Method Name
Polymerase Chain Reaction (PCR) including Restriction Digest
Shipping Instructions
Specimen preferred to arrive within 96 hours of collection.
Specimen Required
Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.
Specimen Type: Whole blood
Container/Tube:
Preferred: Lavender top (EDTA) or yellow top (ACD)
Acceptable: Any anticoagulant
Specimen Volume: 3 mL
Collection Instructions:
1. Invert whole blood several times to mix blood. Do not aliquot.
2. Send specimen in original tube.
Specimen Type
VariesSpecimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Ambient (preferred) | ||
| Frozen | |||
| Refrigerated | |||
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Interpretation
An interpretive report will be provided.
Day(s) Performed
Tuesday, Thursday
Report Available
6 to 7 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
81401-APOE (apolipoprotein E) (eg, hyperlipoproteinemia type III, cardiovascular disease, Alzheimer disease), common variants (eg, *2, *3, *4)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| APOEG | Apolipoprotein E Genotyping, B | 42315-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 53198 | Result Summary | 50397-9 |
| 53199 | Result | 42315-2 |
| 53200 | Interpretation | 69047-9 |
| 53201 | Reason for Referral | 42349-1 |
| 53202 | Specimen | 31208-2 |
| 53203 | Source | 31208-2 |
| 53204 | Released By | 18771-6 |
Forms
1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file.
-Informed Consent for Genetic Testing (T576)
-Informed Consent for Genetic Testing-Spanish (T826)
2. Molecular Genetics: Neurology Patient Information
3. If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.