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HelpTest Code BIllings Clinic: 1357 Mayo: SLFA Cryptococcus Antigen Screen with Titer, Serum
Reporting Name
Cryptococcus Ag Screen w/Titer, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Aiding in the diagnosis of cryptococcosis
This test should not be used as a test of cure or to guide treatment decisions.
This test should not be used as a screening procedure for the general populations.
Method Name
Lateral Flow Assay (LFA)
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
Reference Values
Negative
Interpretation
The presence of cryptococcal antigen in any body fluid (serum or cerebrospinal fluid) is indicative of cryptococcosis. Specimens that are positive by the lateral flow assay screen are automatically repeated with the same method utilizing dilutions to generate a titer value.
Disseminated infection is usually accompanied by a positive serum test.
Higher Cryptococcus antigen titers appear to correlate with more severe infections. Declining titers may indicate regression of infection. However, monitoring titers to cryptococcal antigen should not be used as a test of cure or to guide treatment decisions. Low-level titers may persist for extended periods of time following appropriate therapy and the resolution of infection.(3)
Day(s) Performed
Monday through Sunday
Report Available
Same day/1 to 2 daysTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
87899
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SLFA | Cryptococcus Ag Screen w/Titer, S | 29903-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 62075 | Cryptococcus Ag Screen w/Titer, S | 29903-2 |
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SLFAT | Cryptococcus Ag Titer, LFA, S | Yes | No |
Testing Algorithm
If result is positive, Cryptococcus titer will be performed at an additional charge.