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Test Code Billings Clinic: 1113 Mayo: CCP Cyclic Citrullinated Peptide Antibodies, IgG, Serum

Reporting Name

Cyclic Citrullinated Peptide Ab, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Evaluating patients suspected of having rheumatoid arthritis (RA)

 

Differentiating RA from other inflammatory arthritis or connective tissue diseases

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK
Heat-treated specimen Reject

Reference Values

<20.0 U (negative)

20.0-39.9 U (weak positive)

40.0-59.9 U (positive)

≥60.0 U (strong positive)

Reference values apply to all ages.

Interpretation

A positive result for cyclic citrullinated peptide (CCP) antibodies may be suggestive of rheumatoid arthritis (RA) if compatible clinical features of disease are present.

 

Significantly elevated levels of CCP antibodies may be useful to identify RA patients with erosive joint disease.

 

A Mayo Clinic prospective clinical evaluation of the CCP antibody test showed a diagnostic sensitivity for RA of 78% with fewer than 5% false positive results in healthy controls (see Cautions).

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86200

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CCP Cyclic Citrullinated Peptide Ab, S 33935-8

 

Result ID Test Result Name Result LOINC Value
CCP Cyclic Citrullinated Peptide Ab, S 33935-8

Forms

If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.

Testing Algorithm

For more information see:

-Connective Tissue Disease Cascade

-Acquired Neuropathy Diagnostic Algorithm