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Test Code Billings Clinic: 1260 Mayo: NMOFC Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay, Spinal Fluid

Reporting Name

NMO/AQP4 FACS, CSF

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD)

 

Diagnosis of autoimmune AQP4 channelopathy

 

Distinguishing NMOSD from multiple sclerosis early in the course of disease

Method Name

Flow Cytometry


Ordering Guidance


 



Necessary Information


Include relevant clinical information, name, phone number, mailing address, and e-mail address (if applicable) of ordering physician.



Specimen Required


Collection Container/Tube: Sterile vial

Specimen Volume: 3 mL


Specimen Type

CSF

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Negative

Interpretation

A positive value is consistent with a neuromyelitis optica spectrum disorder (NMOSD) and justifies initiation of appropriate immunosuppressive therapy at the earliest possible time. This allows early initiation and maintenance of optimal therapy.

 

This autoantibody is not found in healthy subjects.

Day(s) Performed

Monday, Tuesday, Thursday

Report Available

5 to 8 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86053

86053-titer (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NMOFC NMO/AQP4 FACS, CSF 46718-3

 

Result ID Test Result Name Result LOINC Value
38325 NMO/AQP4-IgG FACS, CSF 46718-3

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
NMOTC NMO/AQP4 FACS Titer, CSF No No

Testing Algorithm

When the results of this assay require further evaluation, NMOTC / Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay Titer, Spinal Fluid will be performed at an additional charge.