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Test Code Billings Clinic: 2081 Antiphospholipid Syndrome Panel

Important Note

This in-house testing is not available at this time.  Please order the following alternative tests that will performed at Mayo:

9530  (B2GMG - Beta-2 Glycoprotein 1 Antibodies, IgG and IgM, Serum)

9552  (CLPMG - Phospholipid (Cardiolipin) Antibodies, IgG and IgM, Serum)

8163  (ALUPP - Lupus Anticoagulant Profile, Plasma)

Performing Laboratory

Billings Clinic Laboratory: Immunology, Coagulation

Useful For

Useful for identifying and distinguishing lupus anticoagulants from anticardiolipin antibodies.

  • Antiphospholipid antibodies are present in 0% to 5% of the general population and in 12% or more of patients with thrombosis.
  • These antibodies are associated with an increased risk for arterial or venous thrombosis, thrombocytopenia, and fetal loss.
  • Associations with cardiac valve disease, livedo reticularis, and other features are also recognized.
  • In a recent prospective study involving individuals with antiphospholipid antibodies, the incidence of thrombosis per year was 1% in individuals with no history of thrombosis, 4% in patients with systemic lupus erythematous, 5.5% in patients with a history of thrombosis, and 6% in individuals with high titer IgG anticardiolipin antibody (>40 units).

Methodology

Chemiluminescent Immunoassay - beta-2 glycoprotein 1 antibody, IgG and IgM; phospholipid antibodies (cardiolipin antibodies), IgG and IgM

 

Optical - DRVVT

Specimen Requirements

See “Coagulation Studies—Billings Clinic Laboratory” under "Resources"

Sodium citrate plasma and serum are required for this test.

 

Plasma for DRVVT

  • Draw blood in a light blue-top (3.2% sodium citrate) tube(s).
  • Immediately after draw, gently invert tube(s) at least 6 times to mix well.
  • Spin down, remove plasma, spin plasma again, and place 2 mL of citrate, platelet-poor plasma into 2 plastic vials each containing 1 mL.
  • Label specimen appropriately (plasma).
  • Glass vial is not acceptable.
  • Freeze specimen immediately at -20° C.
  • Send specimen frozen.
  • Double-centrifuged specimens are critical for accurate results as platelet contamination may cause spurious results.
  • Patient should not be on Coumadin® or heparin.
  • Correction of the anticoagulant to blood ratio is required for patient hematocrits >55% for the light blue-top tube.

Serum for All Other Tests

  • Draw blood in a plain, red-top tube(s) or a serum gel tube(s).
  • Spin down and send 1 mL of serum frozen in plastic vial.
  • Label specimen appropriately (serum for all other tests).

Storage/Stability

Specimen Type Temperature Time
Serum Refrigerated 48 hours
  Frozen (preferred) 1 year
  Ambient (spun) 8 hours

 

Reject Due To

  • Gross Hemolysis
  • Gross Lipemia
  • Gross Icterus

Reference Values

Reference values are included with patient’s report.

Day(s) Test Set Up

Saturday: DRVVT

Friday: beta-2 glycoprotein 1 antibody, IgG and IgM; phospholipid antibodies (cardiolipin antibodies), IgG; phospholipid antibodies (cardiolipin antibodies), IgM

Test Classification and CPT Coding

85612 - DRVVT; undiluted

85613 - DRVVT; diluted (if appropriate)

86146 X 2 - beta-2 glycoprotein 1 antibody, IgG and IgM

86147 x 2 - phospholipid antibodies (cardiolipin antibodies), IgG and IgM

LOINC Code Information

Reporting Name LOINC Code
Beta-2-Glycoprotein 1 IgG, Ab 44448-9
Beta-2-Glycoprotein 1 IgM, Ab 44449-7
Anti-Cardiolipin Ab, IgG 3181-5
Anti-Cardiolipin Ab, IgM 3182-3
DRVVT Screen 6303-2
DRVVT Confirm(as appropriate) 57838-5

 

Profile/Testing Information

 

Profile Information:
Beta-2 Glycoprotein 1 Antibody, IgM Phospholipid Antibodies (Cardiolipin Antibodies), IgG
Beta-2 Glycoprotein 1 Antibody, IgG Phospholipid Antibodies (Cardiolipin Antibodies), IgM
Dilute Russell’s Viper Venom Time (DRVVT)  
Reflex Tests (at an additional charge):
DRVVT Confirmation DRVVT Mixing Study 1:1
DRVVT Confirmation 1:1  

Reflex Information:

This test may automatically reflex to other tests. An additional fee may be added.

 

The ordering physician/provider must indicate if the reflex test is NOT DESIRED. Indicate on order if no reflex test is desired.