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Test Code Billings Clinic: 2976 MAYO:CIDP Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, Serum


Ordering Guidance


Multiple neurological phenotype-specific autoimmune/paraneoplastic evaluations are available. For more information as well as phenotype-specific testing options, refer to Autoimmune Neurology Test Ordering Guide.

 

For a list of antibodies performed with each evaluation, see Autoimmune Neurology Antibody Matrix.



Specimen Required


Patient Preparation: For optimal antibody detection, it is recommended collecting the specimen before initiation of immunosuppressant medication.

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.

Useful For

Evaluating for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and related demyelinating peripheral neuropathies

Profile Information

Test ID Reporting Name Available Separately Always Performed
CIDPI CIDP/NP Interpretation, S No Yes
CONCS Contactin-1 IgG CBA, S No Yes
NF4FS Neurofascin-155 IgG4, S No Yes

Method Name

CONCS: Cell Binding Assay (CBA)

NF4FS: Flow Cytometry (FCM)

CIDPI: Medical Interpretation

Reporting Name

CIDP/NP Evaluation, S

Specimen Type

Serum

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Contactin-1 IgG: Negative

Neurofascin-155 IgG4: Negative

Interpretation

Seropositivity for contactin-1 IgG is consistent with an immune-mediated demyelinating polyradiculoneuropathy/polyradiculopathy.

 

Seropositivity for neurofascin-155 IgG4 is consistent with an immune-mediated demyelinating polyradiculoneuropathy.

Day(s) Performed

CONCS: Monday through Thursday, Sunday

NF4FS: Monday, Friday

Report Available

5 to 10 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86255 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CIDP CIDP/NP Evaluation, S 101447-1

 

Result ID Test Result Name Result LOINC Value
614591 Neurofascin-155 IgG4, S 100845-7
616444 CIDP/NP Interpretation, S 69048-7
616442 Contactin-1 IgG CBA, S 101448-9