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Test Code Billings Clinic: 3235 Integrated Genetcis: 310 AFP Maternal, Serum, Integrated Genetics

Performing Laboratory

Integrated Genetics

Useful For

MSAFP is a single marker screening test performed on a maternal serum sample collected in the second trimester between 15 weeks / 0 days and 23 weeks / 6 days (15.0 - 23.9 weeks). The results provide a risk assessment for fetal open neural tube defects. It is appropriate to order this test following CVS or first trimester screening for fetal Down syndrome, as these analyses do not screen for open neural tube defects.

Methodology

Immunochemiluminometric assay (ICMA)

Specimen Requirements

Contact Billings Clinic Laboratory at 866-232-2522 prior to specimen draw for specific instructions.

  • Draw blood in a serum gel tube(s).
  • Spin down and send 3 mL of maternal serum refrigerated.
  • If there is a delay in transport of ≥7 days, send specimen frozen in plastic vial.

Note:  The following information is required for processing:


1. Maternal date of birth (not age), weight, and race

2. Number of fetuses in this pregnancy
3. Is patient an insulin-dependent diabetic?
4. Family history of neural tube defect (NTD)?
5. Previous Down syndrome pregnancy?
6. Gestational age calculation (provide at least 1 of the following):


A. Gestation by ultrasound on the date ultrasound was performed
      Note:  Do not extrapolate to draw date.
B. First day of last menstrual period
C. Gestation by physical exam
D. Expected date of delivery (EDD)

Reject Due To

  • Gross hemolysis
  • Gross lipemia
  • Quantity not sufficient for analysis

Reference Values

Reference values are included with patient’s report.

Day(s) Test Set Up

Monday through Saturday

Test Classification and CPT Coding

82105 - Alpha-fetoprotein (AFP); serum