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HelpTest Code Billings Clinic: 3252 Mayo: FIERA IgE Receptor Antibody
Specimen Required
Container/Tube:
Preferred: Red top tube
Acceptable: Serum gel tube
Specimen Volume: 1.0 mL
Collection Instructions: Draw blood in a plain, red-top tube(s) or serum gel tube(s). Separate serum from cells immediately by centrifugation and aliquot in a polypropylene or similar plastic tube. Send 1 mL of serum frozen in plastic vial.
Useful For
The test detects functional autoantibodies to the Fc-epsilon receptor (high affinity IgE receptor) or to IgE and is useful in the evaluation of chronic urticaria.
Method Name
Flow Cytometry
Reporting Name
IgE Receptor AntibodySpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Frozen (preferred) | 365 days | |
| Refrigerated | 7 days | ||
| Ambient | 48 hours |
Reject Due To
| Hemolysis | Mild OK; Gross reject |
| Lipemia | NA |
| Icterus | NA |
| Other | NA |
Reference Values
0-12
Interpretation
Chronic autoimmune urticaria (CIU) may be associated with autoantibodies to the high affinity IgE receptor (Fc-epsilon R1) or to IgE. In the presence of the autoantibodies, cross-linking of the Fc-epsilon-R1 receptor occurs, leading to basophil activation. The laboratory tests for the activation of donor basophils by CIU serum by analyzing the expression of the basophil specific ectoenzyme, CD203c. CD203c is upregulated on the surface of basophils following activation. A positive result is indicative of the presence of autoantibodies associated with CUI, but may also be due to other basophil-activating serum factors. Results must be correlated with clinical findings. The reference range was developed by the National Jewish Health Advanced Diagnostic Laboratories by analyzing 80 healthy control serum samples.
Day(s) Performed
Monday, Thursday
Report Available
11 to 14 daysPerforming Laboratory
National Jewish HealthTest Classification
This test uses a kit/reagent designated by the manufacturer as "for research use, not for clinical use" as well as one or more reagents classified as an analyte specific reagent (ASR). The performance characteristics of this test have been validated by Advanced Diagnostic Laboratories at National Jewish Health. It has not been cleared or approved by the US Food and Drug Administration. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity clinical laboratory testing.CPT Code Information
88184
88185 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FIERA | IgE Receptor Antibody | Not Provided |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z5810 | CD203c (Percent of Basophils) | Not Provided |
| Z5811 | Interpretation: | Not Provided |