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Test Code Billings Clinic:4105 Mayo:THEO Theophylline, Serum

Reporting Name

Theophylline, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Assessing and adjusting theophylline dosage for optimal therapeutic level

 

Assessing theophylline toxicity

Method Name

Kinetic Interaction of Microparticles in a Solution (KIMS)


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged and the serum aliquoted into a plastic vial within 2 hours of collection.


Specimen Type

Serum

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject

Reference Values

Therapeutic:

Bronchodilation: 8.0-20.0 mcg/mL

Neonatal apnea (≤4 weeks old): 6.0-13.0 mcg/mL

Critical value: >20.0 mcg/mL

Interpretation

Response to theophylline is directly proportional to the serum level.

 

Patients usually receive the best response when the serum level is above 8.0 mcg/mL, with minimal toxicity experienced as long as the level is less than or equal to 20.0 mcg/mL.

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 2 days

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80198

LOINC Code Information

Test ID Test Order Name Order LOINC Value
THEO Theophylline, S 4049-3

 

Result ID Test Result Name Result LOINC Value
8661 Theophylline, S 4049-3

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.