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Test Code Billings Clinic: 4571 Hepatitis Bs Antibody (Anti-HBs) Titer, Quantitative, Serum

Important Note

Assay performance characteristics for this assay have not been established in pregnant women.

Performing Laboratory

Billings Clinic Laboratory: Chemistry

 

See “Viral Hepatitis Serologic Profiles—Billings Clinic Laboratory” under Resources

Useful For

  • Identifying previous exposure to hepatitis B virus
  • Determining adequate immunity from hepatitis B vaccination
  • This assay is FDA-approved for in vitro diagnostic use and not for screening cell, tissue, and blood donors.

Methodology

Chemiluminescence Immunoassay

 

Specimen Requirements

Serum should be physically separated from cells as soon as possible with a maximum limit of two hours from the time of collection.

 

  • Draw blood in a serum gel tube(s).
  • Spin down and send 2 mL of serum frozen in plastic vial.
  • Draw date is required on request form for processing.

Storage/Stability

Specimen Type Temperature Time
Serum Refrigerated 7 days
  Frozen (preferred) 1 month
  Ambient 7 days

 

Reject Due To

  • Heat-inactivated specimen
  • Grossly hemolyzed specimen

Reference Values

INTERPRETIVE GUIDE


Anti-HBs level after vaccination

  • <8.0 mIU/mL (indicates susceptibility to hepatitis B; individual is considered not immune to HBV infection; revaccinate 3 months after first series)
  • ≥8.0-<12.0 mIU/mL (Indicates grayzone.  The immune status of the individual should be further assessed by considering factors such as clinical status, follow-up testing, associated risk factors, and the use of other diagnostic information.  Consider revaccination 3 months after first series.)
  • ≥12.0 mIU/mL (Positive for antibody to hepatitis B; no further vaccination/booster necessary per the Center of Disease Control recommendations)

Day(s) Test Set Up

Daily

Test Classification and CPT Coding

86706 - Hepatitis B surface antibody (HBsAb)

LOINC Code Information

Reporting Name LOINC Code
HBsAb, Quant 5193-8