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Test Code Billings Clinic: 4860 Mayo: TOPI Topiramate, Serum

Reporting Name

Topiramate, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring serum concentrations of topiramate

 

Assessing compliance

 

Assessing potential toxicity


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL serum

Collection Instructions:

1. Draw blood immediately before next scheduled dose.

2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.


Specimen Type

Serum Red

Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Anticonvulsant: 5.0-20.0 mcg/mL

Interpretation

Most individuals display optimal response to topiramate with serum levels 5.0 to 20.0 mcg/mL when used to control seizures. Some individuals may respond well outside of this range or may display toxicity within the therapeutic range; thus, interpretation should include clinical evaluation.

 

Therapeutic ranges are based on specimens collected at trough (ie, immediately before the next dose).

 

Toxic levels have not been well established.

Day(s) Performed

Monday through Friday

Report Available

1 to 2 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80201

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TOPI Topiramate, S 17713-9

 

Result ID Test Result Name Result LOINC Value
81546 Topiramate, S 17713-9

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Neurology Specialty Testing Client Test Request (T732)

-Therapeutics Test Request (T831)