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Test Code Billings Clinic: 4876 Mayo: OMHC Oxcarbazepine Metabolite (MHC), Serum

Reporting Name

Oxcarbazepine Metabolite (MHC), S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring serum concentration during oxcarbazepine therapy

 

Assessing compliance

 

Assessing potential toxicity

Method Name

High-Turbulence Liquid Chromatography Mass Spectrometry (HTLC-MS/MS)


Specimen Required


Collection Container/Tube: Red top (serum gel/SST is not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Collect specimen immediately before next scheduled dose.

2. Centrifuge and aliquot serum into plastic vial within 2 hours of collection.


Specimen Type

Serum Red

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Oxcarbazepine metabolite: 3-35 mcg/mL

Interpretation

Therapeutic ranges are based on specimens drawn at trough (ie, immediately before the next dose). Most individuals display optimal response to oxcarbazepine therapy when serum levels of the metabolite (measured in this assay) are between 3 and 35 mcg/mL. Some individuals may respond well outside of this range, or may display toxicity within the therapeutic range. Thus, interpretation should include clinical evaluation.

Day(s) and Time(s) Performed

Tuesday through Saturday; 12 a.m.

Saturday; 1 p.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80183

LOINC Code Information

Test ID Test Order Name Order LOINC Value
OMHC Oxcarbazepine Metabolite (MHC), S 31019-3

 

Result ID Test Result Name Result LOINC Value
81030 Oxcarbazepine Metabolite (MHC), S 31019-3

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Neurology Specialty Testing Client Test Request (T732)

-Therapeutics Test Request (T831)