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Test Code Billings Clinic: 4908 Mayo: UE3 Estriol, Unconjugated, Serum

Reporting Name

Estriol, Unconjugated, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

As an adjunct biomarker in the prenatal diagnosis of disorders of fetal steroid metabolism, including Smith-Lemli-Opitz syndrome (1,2) and X-linked ichthyosis (placental sulfatase deficiency disorders)

 

Evaluating primary or secondary fetal adrenal insufficiency after excluding other rare single gene defects, including aromatase deficiency, 17 alpha-hydroxylase deficiency and/or various forms of congenital adrenal hyperplasia

Method Name

Immunoenzymatic Assay


Specimen Required


Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.6 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  90 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Reference Values

Males: <0.07 ng/mL

Females: <0.08 ng/mL

 

For SI unit Reference Values, see www.mayocliniclabs.com/order-tests/si-unint-conversion.html

Interpretation

A low uE3 level can indicate the possibility of aromatase deficiency, congenital adrenal hyperplasia, primary or secondary (including maternal corticosteroid therapy) fetal adrenal insufficiency and/or fetal demise.

 

This test is reported in ng/mL only. If the multiple of the median (MoM) is desired, please consider ordering QUAD1 / Quad Screen (Second Trimester) Maternal, Serum.

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82677

LOINC Code Information

Test ID Test Order Name Order LOINC Value
UE3 Estriol, Unconjugated, S 2250-9

 

Result ID Test Result Name Result LOINC Value
UE3 Estriol, Unconjugated, S 2250-9