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Test Code Billings Clinic: 4911 Mayo: WNC West Nile Virus Antibody, IgG and IgM, Spinal Fluid

Reporting Name

West Nile Virus Ab, IgG and IgM,CSF

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Aids in diagnosis of central nervous system infection with West Nile virus

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Specimen Type

CSF


Specimen Required


Supplies: Aliquot Tube, 5 mL (T465)

Collection Container/Tube: Sterile vial

Submission Container/Tube: Plastic, 5-mL aliquot tube (T465)

Specimen Volume: 1 mL


Specimen Minimum Volume

0.8 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 7 days
  Frozen  30 days

Reject Due To

Gross hemolysis Reject

Reference Values

IgG: Negative

IgM: Negative

Reference values apply to all ages.

Interpretation

IgM:

A positive result is consistent with the acute phase of West Nile virus (WNV) meningitis or encephalitis. In the very early stages of acute WNV infection, IgM may be detectable in cerebrospinal fluid (CSF) before it becomes detectable in serum.

 

A negative result may indicate absence of disease. However, specimens drawn too early in the acute phase may be negative for IgM-class antibodies to WNV. If WNV central nervous system infection is suspected, a second specimen should be collected in 1 to 2 weeks and tested.

 

IgG:

A positive result may indicate recent or past central nervous system (CNS) infection with WNV. Clinical correlation is necessary.

 

This assay is unable to distinguish between intrathecal antibody synthesis and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. Positive results should be interpreted with other laboratory and clinical data prior to a diagnosis of CNS infection.

Day(s) and Time(s) Performed

Monday, Wednesday, Friday; 9 a.m.

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

IgG: 86789

IgM: 86788

LOINC Code Information

Test ID Test Order Name Order LOINC Value
WNC West Nile Virus Ab, IgG and IgM,CSF 94853-9

 

Result ID Test Result Name Result LOINC Value
WNGC West Nile Virus Ab, IgG, CSF 77953-8
WNMC West Nile Virus Ab, IgM, CSF 29569-1
WNVCI West Nile CSF Interpretation 69048-7

Profile Information

Test ID Reporting Name Available Separately Always Performed
WNGC West Nile Virus Ab, IgG, CSF No Yes
WNMC West Nile Virus Ab, IgM, CSF No Yes
WNVCI West Nile CSF Interpretation No Yes

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.

Testing Algorithm

The following algorithms are available in Special Instructions:

-Meningitis/Encephalitis Panel Algorithm

-Mosquito-borne Disease Laboratory Testing