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Test Code Billings Clinic: 4951 Mayo: LEVE Levetiracetam, Serum

Reporting Name

Levetiracetam, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring serum concentration of levetiracetam, particularly in patients with kidney disease

 

Assessing compliance with levetiracetam therapy

 

Assessing potential toxicity of levetiracetam

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)


Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Draw blood immediately before next scheduled dose.

2. For sustained-release formulations only, draw blood a minimum of 12 hours after last dose.

3. Within 2 hours of collection, centrifuge, and aliquot serum into a plastic vial


Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

10.0-40.0 mcg/mL

Interpretation

Most individuals display optimal response to levetiracetam with serum levels 10.0 to 40.0 mcg/mL. Some individuals may respond well outside of this range or may display toxicity within the therapeutic range; thus, interpretation should include clinical evaluation.

 

Toxic levels have not been well established. Therapeutic ranges are based on specimen collected at trough (ie, immediately before the next dose).

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80177

LOINC Code Information

Test ID Test Order Name Order LOINC Value
LEVE Levetiracetam, S 30471-7

 

Result ID Test Result Name Result LOINC Value
83140 Levetiracetam, S 30471-7

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Neurology Specialty Testing Client Test Request (T732)

-General Request (T239)

-Therapeutics Test Request (T831)