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HelpTest Code Billings Clinic: 6910 Mayo: OPATU Opiates Confirmation, Random, Urine
Reporting Name
Opiate Confirmation, UPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Detection and quantification of codeine, hydrocodone, oxycodone, morphine, hydromorphone, oxymorphone, noroxycodone, noroxymorphone, norhydrocodone, dihydrocodeine, and naloxone in urine
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Ordering Guidance
For situations where chain of custody is required, a Chain of Custody Kit (T282) is available. For chain-of-custody testing, order OPATX / Opiates Confirmation, Chain of Custody, Random, Urine.
Additional drug panels and specific requests are available; call 800-533-1710.
Additional Testing Requirements
If urine creatinine is required or adulteration of the sample is suspected, the following test should also be ordered, ADULT / Adulterants Survey, Random, Urine.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Plastic urine container
Submission Container/Tube: Plastic, 5-mL tube
Specimen Volume: 3 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Additional Information:
1. No specimen substitutions.
2. STAT requests are not accepted for this test.
3. Submitting less than 1 mL will compromise our ability to perform all necessary testing.
Specimen Type
UrineSpecimen Minimum Volume
2.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 14 days |
Reject Due To
| Gross hemolysis | OK |
| Gross icterus | OK |
Reference Values
Negative
Cutoff concentrations by liquid chromatography tandem mass spectroscopy:
Codeine: 25 ng/mL
Dihydrocodeine: 25 ng/mL
Hydrocodone: 25 ng/mL
Norhydrocodone: 25 ng/mL
Hydromorphone: 25 ng/mL
Oxycodone: 25 ng/mL
Noroxycodone: 25 ng/mL
Oxymorphone: 25 ng/mL
Noroxymorphone: 25 ng/mL
Naloxone: 25 ng/mL
Morphine: 25 ng/mL
Interpretation
This test reports the total urine concentration; this is the sum of the unconjugated and conjugated forms of the parent drug.
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80361
80365
80362
G0480 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| OPATU | Opiate Confirmation, U | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 6543 | Codeine-by LC-MS/MS | 16250-3 |
| 42000 | Dihydrocodeine-by LC-MS/MS | 19448-0 |
| 21177 | Hydrocodone-by LC-MS/MS | 16252-9 |
| 42001 | Norhydrocodone-by LC-MS/MS | 61422-2 |
| 21179 | Hydromorphone-by LC-MS/MS | 16998-7 |
| 21178 | Oxycodone-by LC-MS/MS | 16249-5 |
| 42002 | Noroxycodone-by LC-MS/MS | 61425-5 |
| 35023 | Oxymorphone-by LC-MS/MS | 17395-5 |
| 42003 | Noroxymorphone-by LC-MS/MS | 90894-7 |
| 42004 | Naloxone-by LC-MS/MS | 77207-9 |
| 6542 | Morphine-by LC-MS/MS | 16251-1 |
| 21180 | Opiates Interpretation | 69050-3 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.