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Test Code Billings Clinic: 7429 IgVH Hypermutation Analysis, PCR

Performing Laboratory

NeoGenomics Laboratory

Useful For

In CLL patients, a clonal B-cell population with a hypermutated IgH V region suggests a more mature malignancy and correlates with a more favorable prognosis and a significantly longer median survival time than those with unmutated IgH V region.

 

 

Methodology

Polymerase Chain Reaction (PCR)

Specimen Requirements

  • Do not centrifuge
  • Send sample refrigerated. Use a refrigerated cold pack for transport.
  • Make sure cold pack is not in direct contact with the specimen.
  • DO NOT FREEZE

Submit 1 or both of the following specimens:

 

Bone Marrow

Send 2 - 3 mL of bone marrow aspirate in an EDTA tube (purple top).

 

Whole Blood

Send 2 - 3 mL of peripheral blood in an EDTA tube (purple top).

Reference Values

An interpretive report will be provided.

Day(s) Test Set Up

Monday - Friday, by 3 pm

Test Classification and CPT Coding

81263 – IGH@ variable region somatic mutation analysis

 

LOINC Code Information

Reporting Name LOINC Code
IgVH Hypermutation Analysis In process