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HelpTest Code Billings Clinic: 7496 Mayo: VORI Voriconazole, Serum
Reporting Name
Voriconazole, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Monitoring trough levels of voriconazole is suggested for:
-Individuals with reduced liver function
-Individuals with cytochrome P450 (CYP) 2C19 alterations associated with poor metabolic function
-Patients taking other medications that affect CYP2C19 activity
-Patients experiencing potential toxicity
Monitoring trough levels may be reasonable in patients who are not responding optimally or have drug interactions that may decrease voriconazole levels or to ensure adequate oral absorption
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Specimen Required
Collection Container/Tube: Red top (serum gel/SST not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Specimen Type
Serum RedSpecimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
1.0-5.5 mcg/mL
Trough level (ie, immediately before next dose) monitoring is recommended.
Interpretation
Trough levels above 6 mcg/mL (and especially >10 mcg/mL) have been associated with toxicity in several reports.
Trough levels below 1 mcg/mL have been associated with suboptimal response in several reports.
Day(s) Performed
Monday through Sunday
Report Available
Same day/1 to 2 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80285
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| VORI | Voriconazole, S | 38370-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 88698 | Voriconazole, S | 38370-3 |