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HelpTest Code Billings Clinic: 7609 Mayo: INHAB Inhibin A and B, Tumor Marker, Serum
Reporting Name
Inhibin A and B, Tumor Marker, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Aiding in the diagnosis of granulosa cell tumors and mucinous epithelial ovarian tumors
Monitoring of patients with granulosa cell tumors and epithelial mucinous-type tumors of the ovary known to secrete inhibin A or overexpress inhibin B
Method Name
INHA: Immunoenzymatic Assay
INHB: Enzyme-Linked Immunosorbent Assay (ELISA)
Specimen Required
Supplies: Sarstedt Aliquot Tube 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1.1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
0.9 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days | ||
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
INHIBIN A, TUMOR MARKER
Males: <5.0 pg/mL
Females
<11 years: <5.0 pg/mL
11-17 years: <98 pg/mL
Premenopausal: <98 pg/mL
Postmenopausal: <5.0 pg/mL
INHIBIN B
Males
<15 days: 68-373 pg/mL
15-180 days: 42-516 pg/mL
6 months-7 years: 24-300 pg/mL
8-30 years: 47-383 pg/mL
31-72 years: <358 pg/mL
>72 years: Not established
Females
≤12 years: <183 pg/mL
13-41 years regular Cycle (Follicular Phase): <224 pg/mL
42-51 years regular Cycle (Follicular Phase): <108 pg/mL
13-51 years regular Cycle (Luteal Phase): <80 pg/mL
>51 years (Postmenopausal): <12 pg/mL
Interpretation
Inhibin A levels are elevated in approximately 70% of patients with granulosa cell tumors and in approximately 20% of patients with epithelial ovarian tumors.
Inhibin B levels are elevated in approximately 89% to 100% of patients with granulosa cell tumors and in approximately 55% to 60% of patients with epithelial ovarian tumors.
A normal inhibin A or B level does not rule out a mucinous or granulosa ovarian cell tumor.
For monitoring of patients with known ovarian cancer, inhibin A and B levels decrease shortly after surgery. Elevations of inhibin A or B after treatment are suggestive of residual, recurrent, or progressive disease. In patients with recurrent disease, inhibin A or B elevation seems to be present earlier than clinical symptoms. Patients in remission show normal levels of inhibin A and B.
For infertility evaluation, an inhibin B level in the postmenopausal range is suggestive of a diminished or depleted ovarian reserve.
Day(s) Performed
Monday, Wednesday, Friday
Report Available
2 to 4 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83520-Inhibin B
86336-Inhibin A
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| INHAB | Inhibin A and B, Tumor Marker, S | 87426-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| INHA | Inhibin A, Tumor Marker, S | 23883-2 |
| 88722 | Inhibin B, S | 56940-0 |
Forms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| INHA | Inhibin A, Tumor Marker, S | Yes | Yes |
| INHB | Inhibin B, S | Yes | Yes |