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Test Code Billings Clinic: 7984 Mayo: APOLB Apolipoprotein B, Serum

Reporting Name

Apolipoprotein B, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Assessment of cardiovascular risk

 

Follow-up studies in individuals with basic lipid measures inconsistent with risk factors or clinical presentation

 

Definitive studies of cardiac risk factors in individuals with significant family histories of coronary artery disease or other increased risk factors

 

Confirmation of suspected abetalipoproteinemia or hypobetalipoproteinemia

Method Name

Automated Turbidimetric Immunoassay


Ordering Guidance


If only apolipoprotein B is required, order this test.

 

If both apolipoprotein A and apolipoprotein B are required, order APOAB / Apolipoprotein A1 and B, Serum.



Shipping Instructions


Send specimen refrigerated.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL serum

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Type

Serum

Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 8 days
  Frozen  60 days
  Ambient  24 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus Reject

Reference Values

Less than 2 years: Not established

 

2-17 years:

Acceptable: <90 mg/dL

Borderline high: 90-109 mg/dL

High: ≥110 mg/dL

 

≥18 years:

Desirable: <90 mg/dL

Above Desirable: 90-99 mg/dL

Borderline high: 100-119 mg/dL

High: 120-139 mg/dL

Very high: ≥140 mg/dL

Interpretation

Elevated apolipoprotein B (ApoB) confers increased risk of coronary artery disease. ApoB can be used as a therapeutic target analogous to non-HDL-C and LDL-C.

 

Apolipoprotein B values less than 48 mg/dL are considered very low (<2.5th population percentile). Possible causes include aggressive lipid-lowering therapy, malnutrition, hepatobiliary disease or drug interactions. Decreased ApoB may indicate hypobetalipoproteinemia (HBL). Genetic testing for HBL is available (HYPBG / Hypobetalipoproteinemia Gene Panel, Varies).

Day(s) Performed

Monday through Sunday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82172

LOINC Code Information

Test ID Test Order Name Order LOINC Value
APOLB Apolipoprotein B, S 1884-6

 

Result ID Test Result Name Result LOINC Value
APOLB Apolipoprotein B, S 1884-6

Forms

If not ordering electronically, complete, print, and send 1 of the following with the specimen:

-Cardiovascular Test Request Form (T724)

-General Test Request (T239)