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Test Code Billings Clinic: 8020 Anti-Ro52 (SSA-52), IgG, Serum

Additional Codes

Ordering Mnemonic
MayoAccess: BCL867

 

Performing Laboratory

Billings Clinic Laboratory: Immunology

Useful For

  • The presence of anti-Ro52 autoantibodies, in conjunction with clinical findings and other laboratory tests, is an aid in the diagnosis of Systemic Lupus Erythematosus, Sjögren’s Syndrome, Systemic Sclerosis, and Idiopathic Inflammatory Myopathies

  • Ro52 autoantibodies are frequently present in the sera of patients with SS (40-70%) or SLE (20-40%).

  • Anti-Ro antibodies have special diagnostic significance in congenital heart block. Isolated congenital complete atrioventricular block (CAVB) shows a close association with maternal anti-Ro and anti-SS-B (La) antibodies; the highest relative risks of CAVB are seen in offspring of mothers with antibodies against 52-kDa Ro and 48-kDa SS-B proteins.

Methodology

Chemiluminescent Immunoassay

Specimen Requirements

  • Draw blood in a serum gel tube(s).
  • Spin down and send 0.5 mL of serum frozen in plastic vial.

Storage/Stability

Specimen Type Temperature Time
Serum Refrigerated 2 weeks
  Frozen (preferred) 1 year
  Ambient (Spun) 48 hours

 

Reject Due To

  • Specimen other than serum
  • Microbially contaminated specimen
  • Heat-treated specimen

Reference Values

<20 CU (Chemiluminescent Units)

 

Interpretive Remark:  The following results were obtained with the INOVA QUANTA Flash Ro52 Chemiluminescent immunoassay.  Values obtained with different manufacturers' assay methods may not be used interchangeably.

Day(s) Test Set Up

Tuesday, Thursday

Test Classification and CPT Coding

86235 - Extractable nuclear antigen, antibody to, any method, each antibody

LOINC Code Information

Reporting Name LOINC Code
Anti-Ro52, IgG 70257-1