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HelpTest Code Billings Clinic: 8092 Mayo: MMRV Measles, Mumps, Rubella, and Varicella (MMRV) Immune Status Profile, Serum
Reporting Name
MMRV Immune Status Profile, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Determining immune status of individuals to measles, mumps, rubella, and varicella-zoster viruses (VZV)
Documentation of previous infection with measles, mumps, rubella, or VZV in an individual without a previous record of immunization to these viruses
Method Name
Multiplex Flow Immunoassay (MFI)
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Instructions: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
| Heat-inactivated specimen | Reject |
Reference Values
MEASLES, MUMPS and VARICELLA:
Vaccinated: Positive (≥1.1 AI)
Unvaccinated: Negative (≤0.8 AI)
Reference values apply to all ages
RUBELLA:
Vaccinated: Positive (≥1.0 AI)
Unvaccinated: Negative (≤0.7 AI)
Reference values apply to all ages
Interpretation
The reported AI value is for reference only. This is a qualitative test, and the numeric value of the AI is not indicative of the amount of antibody present. AI values above the manufacturer recommended cutoff for this assay indicate that specific antibodies were detected, suggesting prior exposure or vaccination.
Positive measles, mumps, varicella-zoster viruses (VZV): Antibody Index (AI) value ≥1.1
Positive rubella: AI Value ≥1.0
-The presence of detectable IgG-class antibodies to these viruses indicates prior exposure through infection or immunization. Individuals testing positive for IgG-class antibodies to measles, mumps, rubella, or VZV are considered immune.
Equivocal measles, mumps, VZV: AI value 0.9-1.0
Equivocal rubella: AI value 0.8-0.9
-Submit an additional sample for testing in 10 to 14 days to demonstrate IgG seroconversion if recently vaccinated or if otherwise clinically indicated.
Negative measles, mumps, VZV: AI value ≤0.8
Negative rubella: AI value ≤0.7
-The absence of detectable IgG-class antibodies to measles, mumps, rubella, or VZV suggests no prior exposure to these viruses or the lack of a specific immune response to immunization.
Day(s) Performed
Monday through Saturday
Report Available
Same day/1 dayTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86735
86762
86765
86787
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MMRV | MMRV Immune Status Profile, S | 104688-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| VZG | Varicella-Zoster Ab, IgG, S | 15410-4 |
| RBG | Rubella Ab, IgG, S | 40667-8 |
| MUMG | Mumps Ab, IgG, S | 6476-6 |
| ROG | Measles (Rubeola) Ab, IgG, S | 35275-7 |
| DEXG3 | Measles IgG Antibody Index | 5244-9 |
| DEXG2 | Rubella IgG Antibody Index | 5334-8 |
| DEXG5 | Mumps IgG Antibody Index | 25418-5 |
| DEXG4 | Varicella IgG Antibody Index | 5403-1 |
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ROPG | Measles (Rubeola) Ab, IgG, S | Yes | Yes |
| MPPG | Mumps Ab, IgG, S | Yes | Yes |
| RBPG | Rubella Ab, IgG, S | Yes | Yes |
| VZPG | Varicella-Zoster Ab, IgG, S | Yes | Yes |