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HelpTest Code Billings Clinic: 8182 Mayo: FLUOX Fluoxetine, Serum
Reporting Name
Fluoxetine, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Monitoring serum concentration of fluoxetine during therapy
Evaluating potential toxicity
Evaluating patient compliance
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Specimen Required
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Draw blood immediately before the next scheduled dose (trough).
2. Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Specimen Type
Serum RedSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 72 hours |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Fluoxetine + Norfluoxetine: 120-500 ng/mL
Interpretation
Most individuals display optimal response to fluoxetine when combined serum levels of fluoxetine and norfluoxetine are between 120 and 500 ng/mL. Some individuals may respond well outside of this range or may display toxicity within the therapeutic range; therefore, interpretation should include clinical evaluation. A toxic range has not been well established.
Day(s) Performed
Wednesday
Report Available
1 to 8 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80299
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FLUOX | Fluoxetine, S | 78437-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 80228 | Fluoxetine, S | 74982-0 |
| 251 | Norfluoxetine, S | 3868-7 |
| 252 | Fluoxetine+Norfluoxetine | 74948-1 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.