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HelpTest Code Billings Clinic: 8201 Mayo: SCOC Coccidioides Antibody, Complement Fixation and Immunodiffusion, Serum
Reporting Name
Coccidioides Ab, CompF/ImmDiff, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Diagnosis of coccidioidomycosis using serum specimens
Method Name
Complement Fixation (CF)
Immunodiffusion
Ordering Guidance
This test is a confirmatory assay for positive screening tests (ie, enzyme immunoassay).
The recommended test to evaluate for possible Coccidioides infection is COXIS / Coccidioides Antibody Screen with Reflex, Serum.
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1.8 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
1.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
Reference Values
COMPLEMENT FIXATION
Negative
If positive, results are titered.
IMMUNODIFFUSION
Negative
Results are reported as positive, negative, or equivocal.
Interpretation
Complement Fixation:
Titer results of 1:2 or higher may suggest active disease; however, titers may persist for months after infection has resolved. Increasing complement fixation (CF) titer results in serial specimens are considered diagnostic of active disease.
Immunodiffusion:
The presence of IgM antibodies may be detectable within 2 weeks after the onset of symptoms; however, the antibody may be detected longer than 6 months after infection.
The presence of IgG antibodies parallels the CF antibodies and may suggest an active or a recent asymptomatic infection with Coccidioides immitis/posadasii; however, antibodies may persist after the infection has resolved.
An equivocal result (a band of nonidentity) cannot be interpreted as significant for a specific diagnosis. However, this may be an indication that a patient should be followed serologically.
Over 90% of primary symptomatic cases will be detected by combined immunodiffusion and CF testing.
Day(s) Performed
Monday through Friday
Report Available
4 to 7 daysTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86635 x 3
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SCOC | Coccidioides Ab, CompF/ImmDiff, S | 87435-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8295 | Coccidioides Ab, CompF, S | In Process |
| 21649 | Coccidioides, IgG, ImmDiff, S | 62459-3 |
| 21648 | Coccidioides, IgM, ImmDiff, S | 62458-5 |
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.