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Test Code Billings Clinic: 8420 Prostate-Specific Antigen (PSA), Diagnostic, Serum

Important Note

This test is appropriately ordered on non-Medicare patients and for Medicare patients when the physician/nonphysician provider (NPP) is requesting the test for non-screening reasons.

Specimens obtained from patients undergoing prostate manipulation, especially needle biopsy and transurethral resection, may show erroneously high results.

Prostate cancer patients under treatment with anti-androgens and LHRH agonists may exhibit markedly reduced levels of PSA.

Men treated for benign prostatic hyperplasia with inhibitors of 5α‑reductase (finasteride) may demonstrate a significant reduction in PSA levels compared to values prior to treatment.

 

Performing Laboratory

Billings Clinic Laboratory: Chemistry

Useful For

  • Evaluating patients with documented prostate problems in whom multiple prostate-specific antigen tests may be necessary per year

  • Monitoring patients with a history of prostate cancer as an early indicator of recurrence and response to treatment

Methodology

Direct Chemiluminescence

Specimen Requirements

  • Draw blood in a red-top (gel) tube(s).
  • Spin down and send 1 mL of serum frozen in plastic vial.

Storage/Stability

Specimen Type Temperature Time
Serum Refrigerated 2 days
  Frozen (preferred) 1 month
  Ambient 8 hours

 

Reject Due To

  • Specimens with greater than 1 freeze / thaw cycle
  • Specimens with apparent contamination
  • Gross hemolysis

Reference Values

0.0 - 4.0 ng/mL

Day(s) Test Set Up

Daily

Test Classification and CPT Coding

84153 - Prostate specific antigen (PSA); total

 

LCD or NCD test. ICD-10 code is required for this test. When appropriate, obtain a properly executed ABN and submit the ABN with test order(s). See “Medical Necessity and Advanced Beneficiary Notice (ABN) Policy and Form” under Resources for a copy of a form and additional information.

LOINC Code Information

Reporting Name LOINC Code
PSA 2857-1