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Test Code Billings Clinic: 8474 Mayo: APCRV Activated Protein C Resistance V (APCRV), Plasma

Reporting Name

Activated Protein Resistance V, P

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Evaluation of patients with incident or recurrent venous thromboembolism (VTE)

 

Evaluation of individuals with a family history of VTE

Method Name

Optical Clot-Based


Advisory Information


Although this assay can be performed in the absence of other coagulation tests and clinical information, it is most reliably performed as part of a consultative coagulation test panel with interpretive reporting (including appropriate testing of the same specimen to evaluate for the presence or absence of coagulation abnormalities or conditions that may affect interpretation of the APC resistance assay). This test is included among a panel of tests designated AATHR / Thrombophilia Profile.



Necessary Information


If a priority specimen, mark request form, give reason, and request a call-back.



Specimen Required


See Coagulation Studies in Special Instructions: Guidelines for Specimen Handling and Processing.

 

Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (citrate)

Submission Container/Tube: Polypropylene vial

Specimen Volume: 1 mL

Collection Instructions:

1. Centrifuge specimen, remove plasma

2. Centrifuge plasma again; remove plasma aliquot without disturbing bottom 0.5 mL

3. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C, or, ideally ≤-40° C

Additional Information:

1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. If priority specimen, mark request form, give reason, and request a call-back.

3. Each coagulation assay requested should have its own vial.


Specimen Type

Plasma Na Cit

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

APCRV RATIO

≥2.3

Pediatric reference range has neither been established nor is available in scientific literature. The adult reference range likely would be applicable to children older than 6 months.

Day(s) and Time(s) Performed

Monday through Friday

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

85307

LOINC Code Information

Test ID Test Order Name Order LOINC Value
APCRV Activated Protein Resistance V, P 13590-5

 

Result ID Test Result Name Result LOINC Value
APCR APCRV Ratio 13590-5
INT55 Interpretation 48591-2

Forms

If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.

Special Instructions