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Test Code Billings Clinic: 8510 Mayo: CAFF Caffeine, Serum

Reporting Name

Caffeine, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring caffeine therapy in neonates

 

Assessing caffeine toxicity in neonates

Method Name

Enzyme Multiplied Immunoassay Technique (EMIT)


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged and the serum aliquoted into a plastic vial within 2 hours of collection.


Specimen Type

Serum

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 28 days
  Ambient  72 hours
  Refrigerated  72 hours

Reject Due To

Gross hemolysis Reject

Reference Values

Therapeutic: 8.0-20.0 mcg/mL

Critical value: ≥30.0 mcg/mL

Interpretation

Optimal pharmacologic response occurs when the serum level is in the range of 8.0 to 20.0 mcg/mL.

 

Toxicity in neonates and adults may be seen when the serum level is above 20.0 mcg/mL.

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 2 days

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80155

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CAFF Caffeine, S In Process

 

Result ID Test Result Name Result LOINC Value
8754 Caffeine, S 3422-3

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.