Test Code Billings Clinic: 8510 Mayo: CAFF Caffeine, Serum
Reporting Name
Caffeine, SPerforming Laboratory

Useful For
Monitoring caffeine therapy in neonates
Assessing caffeine toxicity in neonates
Method Name
Enzyme Multiplied Immunoassay Technique (EMIT)
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Serum gel tubes should be centrifuged within 2 hours of collection.
2. Red-top tubes should be centrifuged and the serum aliquoted into a plastic vial within 2 hours of collection.
Specimen Type
SerumSpecimen Minimum Volume
0.25 mL
Specimen Stability Information
Specimen Type | Temperature | Time |
---|---|---|
Serum | Frozen (preferred) | 28 days |
Ambient | 72 hours | |
Refrigerated | 72 hours |
Reject Due To
Gross hemolysis | Reject |
Reference Values
Therapeutic: 8.0-20.0 mcg/mL
Critical value: ≥30.0 mcg/mL
Interpretation
Optimal pharmacologic response occurs when the serum level is in the range of 8.0 to 20.0 mcg/mL.
Toxicity in neonates and adults may be seen when the serum level is above 20.0 mcg/mL.
Day(s) Performed
Monday through Saturday
Report Available
Same day/1 to 2 daysTest Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80155
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
CAFF | Caffeine, S | In Process |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
8754 | Caffeine, S | 3422-3 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.