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Test Code Billings Clinic: 8749 Mayo: FLEC Flecainide, Serum

Reporting Name

Flecainide, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Optimizing flecainide dosage

 

Assessing flecainide toxicity

 

Monitoring compliance

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions:

1. Draw blood immediately before next scheduled dose.

2. Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.


Specimen Type

Serum Red
Billings Clinic Note:

This test must be drawn in a PLAIN RED TOP - NO GEL

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Trough Value

0.2-1.0 mcg/mL: Therapeutic concentration

>1.0 mcg/mL: Toxic concentration

Interpretation

Flecainide is most effective in premature ventricular contractions suppression at serum concentrations in the range of 0.2 to 1.0 mcg/mL.

 

Serum concentrations above 1.0 mcg/mL are associated with a high rate of cardiac adverse experiences such as conduction defects or bradycardia.

Day(s) Performed

Monday through Friday

Report Available

2 to 5 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80181

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FLEC Flecainide, S 3638-4

 

Result ID Test Result Name Result LOINC Value
9243 Flecainide, S 3638-4

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.