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Test Code Billings Clinic: 8822 Mayo: COM Complement, Total, Serum

Reporting Name

Complement, Total, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Detection of individuals with an ongoing immune process

 

First-tier screening test for congenital complement deficiencies

Method Name

Automated Liposome Lysis Assay


Specimen Required


Patient Preparation: Fasting preferred but not required

Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Immediately after specimen collection, place the tube on wet ice and allow specimen to clot.

2. Centrifuge at 4° C and aliquot serum into 5 mL plastic vial.

3. Within 30 minutes of centrifugation, freeze specimen. Specimen must be placed on dry ice if not frozen immediately.

NOTE: If a refrigerated centrifuge is not available, it is acceptable to use a room temperature centrifuge, provided the specimen is kept on ice before centrifugation, and immediately afterward, the serum is aliquoted and frozen.


Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen 28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

30-75 U/mL

Interpretation

Low levels of total complement (total hemolytic complement) may occur during infections, disease exacerbation in patients with systemic lupus erythematosus, and in patients with immune complex diseases such as glomerulonephritis.

 

Undetectable levels suggest the possibility of a complement component deficiency. Individual complement component assays are useful to identify the specific deficiency.

Day(s) Performed

Monday through Friday

Report Available

1 to 2 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86162

LOINC Code Information

Test ID Test Order Name Order LOINC Value
COM Complement, Total, S 4532-8

 

Result ID Test Result Name Result LOINC Value
COM Complement, Total, S 4532-8