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HelpTest Code Billings Clinic: 8838 Mayo: A1APP Alpha-1-Antitrypsin Phenotype, Serum
Reporting Name
Alpha-1-Antitrypsin PhenotypePerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Identification of homozygous and heterozygous phenotypes of the alpha-1-antitrypsin deficiency
Method Name
A1AP2: Isoelectric Focusing
AATP: Nephelometry
Specimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1.25 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reference Values
ALPHA-1-ANTITRYPSIN
100-190 mg/dL
ALPHA-1-ANTITRYPSIN PHENOTYPE
The interpretive report will identify the alleles present. For rare alleles, the report will indicate whether or not they have been associated with reduced quantitative levels of alpha-1-antitrypsin.
Interpretation
There are greater than 40 alpha-1-antitrypsin (A1A) phenotypes (most of these are associated with normal quantitative levels of protein). The most common normal phenotype is M (M, M1, or M2), and greater than 90% of individuals of European descent are genetically homozygous M (MM).
A1A deficiency is usually associated with the Z phenotype (homozygous ZZ), but SS and SZ are also associated with decreased A1A levels.
Day(s) Performed
Monday through Friday
Report Available
2 to 6 daysTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
82103
82104
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| A1APP | Alpha-1-Antitrypsin Phenotype | 32769-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| AATP | Alpha-1-Antitrypsin, S | 6771-0 |
| 8166 | Alpha-1-Antitrypsin Phenotype | 32769-2 |
Forms
If not ordering electronically, complete, print, and send 1 of the following with the specimen:
-Gastroenterology and Hepatology Test Request (T728)
-General Request (T239)
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| A1AP2 | Alpha-1-Antitrypsin Phenotype | No | Yes |
| AATP | Alpha-1-Antitrypsin, S | Yes, (Order AAT) | Yes |
Testing Algorithm
See Alpha-1-Antitrypsin-A Comprehensive Testing Algorithm in Special Instructions.