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Test Code Billings Clinic: 8917 Mayo: IGE Immunoglobulin E (IgE), Serum

Reporting Name

Immunoglobulin E (IgE), S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Evaluating patients with suspected diseases associated with elevations in total IgE, including allergic disease, primary immunodeficiencies, infections, malignancies, or other inflammatory diseases 

 

Diagnostic evaluation of patients with suspected allergic bronchopulmonary aspergillosis

 

Identifying candidates for omalizumab (anti-IgE) therapy

Method Name

Fluorescence Enzyme Immunoassay (FEIA)


Ordering Guidance


For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Type

Serum

Specimen Minimum Volume

For only total IgE: 0.3 mL
For total IgE and more than 1 allergen: 0.05 mL x number of allergen-specific tests + 0.25 mL dead space

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  90 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK

Reference Values

0-5 months: ≤13 kU/L

6-11 months: ≤34 kU/L

1 and 2 years: ≤97 kU/L

3 years: ≤199 kU/L

4-6 years: ≤307 kU/L

7 and 8 years: ≤403 kU/L

9-12 years: ≤696 kU/L

13-15 years: ≤629 kU/L

16 and 17 years : ≤537 kU/L

18 years or older: ≤214 kU/L

Interpretation

Elevated concentrations of total IgE may be found in a variety of clinical diseases including allergic disease, certain primary immunodeficiencies, infections, inflammatory diseases, and malignancies.

 

Elevated total IgE concentrations may be consistent with a diagnosis of allergic bronchopulmonary aspergillosis, provided other laboratory and clinical criteria are fulfilled.

 

Total IgE concentrations between 30 to 700 kU/L may identify candidates for omalizumab therapy and may help to determine proper therapeutic dosing.

Day(s) Performed

Monday through Friday

Report Available

Same day/1 day to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82785

LOINC Code Information

Test ID Test Order Name Order LOINC Value
IGE Immunoglobulin E (IgE), S 19113-0

 

Result ID Test Result Name Result LOINC Value
IGE Immunoglobulin E (IgE), S 19113-0