Test Code Billings Clinic: 8917 Mayo: IGE Immunoglobulin E (IgE), Serum
Reporting Name
Immunoglobulin E (IgE), SPerforming Laboratory
Mayo Clinic Laboratories in RochesterUseful For
Evaluating patients with suspected diseases associated with elevations in total immunoglobulin E (IgE), including allergic disease, primary immunodeficiencies, infections, malignancies, or other inflammatory diseases
Diagnostic evaluation of patients with suspected allergic bronchopulmonary aspergillosis
Identifying candidates for omalizumab (anti-IgE) therapy
Method Name
Fluorescence Enzyme Immunoassay (FEIA)
Ordering Guidance
For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
For total IgE: 0.3 mL
For total IgE and more than 1 allergen: 0.05 mL x number of allergen-specific tests + 0.25 mL dead space
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 14 days | |
Frozen | 90 days |
Reject Due To
Gross hemolysis | OK |
Gross lipemia | OK |
Reference Values
Results reported in kU/L |
|
Age |
Reference interval |
0-5 months |
≤13 |
6-11 months |
≤34 |
1 and 2 years |
≤97 |
3 years |
≤199 |
4-6 years |
≤307 |
7 and 8 years |
≤403 |
9-12 years |
≤696 |
13-15 years |
≤629 |
16 and 17 years |
≤537 |
18 years and older |
≤214 |
Interpretation
Elevated concentrations of total immunoglobulin E (IgE) may be found in a variety of clinical diseases including allergic disease, certain primary immunodeficiencies, infections, inflammatory diseases, and malignancies.
Elevated total IgE concentrations may be consistent with a diagnosis of allergic bronchopulmonary aspergillosis, provided other laboratory and clinical criteria are fulfilled.
Total IgE concentrations between 30 to 700 KU/L may identify candidates for omalizumab therapy and may help to determine proper therapeutic dosing.
Day(s) Performed
Monday through Friday
Report Available
Same day/1 day to 3 daysTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
82785
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
IGE | Immunoglobulin E (IgE), S | 19113-0 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
IGE | Immunoglobulin E (IgE), S | 19113-0 |