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HelpTest Code Billings Clinic: 8927 Mayo: AAT Alpha-1-Antitrypsin, Serum
Reporting Name
Alpha-1-Antitrypsin, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Workup of individuals with suspected disorders such as familial chronic obstructive lung disease
Diagnosing alpha-1-antitrypsin deficiency
Method Name
Nephelometry
Specimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reference Values
100-190 mg/dL
Interpretation
Patients with serum levels less than 70 mg/dL may have a homozygous deficiency and are at risk for early lung disease. Alpha-1-antitrypsin proteotype testing should be done to confirm the presence of homozygous deficiency alleles.
If clinically indicated, patients with serum levels less than 125 mg/dL should have proteotype testing in order to identify heterozygous individuals. Heterozygotes do not appear to be at increased risk for early emphysema.
Day(s) Performed
Monday through Friday
Report Available
1 to 3 daysTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
82103
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| AAT | Alpha-1-Antitrypsin, S | 6771-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| AAT | Alpha-1-Antitrypsin, S | 6771-0 |
Forms
If not ordering electronically, complete, print, and send 1 of the following with the specimen:
-Gastroenterology and Hepatology Test Request (T728)
-General Request (T239)
Testing Algorithm
For more information see Alpha-1-Antitrypsin-A Comprehensive Testing Algorithm.