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Test Code Billings Clinic: 8950 Mayo: ACE Angiotensin Converting Enzyme, Serum

Reporting Name

Angiotensin Converting Enzyme, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Evaluation of patients with suspected sarcoidosis

Method Name

Spectrophotometry (SP)


Necessary Information


The use of angiotensin converting enzyme (ACE)-inhibiting antihypertensive drugs will cause decreased ACE values. Patients taking ACE inhibitors, such as captopril and enalapril, will have extremely low or unmeasurable ACE activity. Indicate on the request form if the patient is on ACE inhibitors.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial


Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  180 days
  Ambient  24 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

≥18 years: 16-85 U/L

0-17 years: Angiotensin converting enzyme activity may be 20-50% higher in healthy children compared to healthy adults.

 

For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Interpretation

An elevation in the level of serum angiotensin converting enzyme (ACE), along with radiographic evidence of infiltrates or adenopathy and organ biopsies showing noncaseating epithelial granulomas is suggestive of a diagnosis of sarcoidosis.

 

Normal, healthy children and infants are known to have ACE activity levels greater than the adult reference interval.

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82164

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ACE Angiotensin Converting Enzyme, S 2742-5

 

Result ID Test Result Name Result LOINC Value
ACE Angiotensin Converting Enzyme, S 2742-5

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-General Request (T239)

-Cardiovascular Test Request (T724)