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Test Code Billings Clinic: 8985 Mayo: CDP Chlordiazepoxide and Metabolites, Serum

Reporting Name

Chlordiazepoxide and metabolites, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring chlordiazepoxide therapy

 

Assessing toxicity

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)


Shipping Instructions


Ship specimen in amber vial to protect from light.



Specimen Required


Supplies: Amber Frosted Tube, 5 mL (T915)

Collection Container/Tube: Red top (serum get/SST are not acceptable)

Submission Container/Tube: Amber vial

Specimen Volume: 1 mL

Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into an amber vial.


Specimen Type

Serum Red

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days LIGHT PROTECTED
  Ambient  28 days LIGHT PROTECTED
  Frozen  28 days LIGHT PROTECTED

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Therapeutic concentration:

Chlordiazepoxide: 400-3,000 ng/mL

 

Cutoff concentrations by liquid chromatography tandem mass spectrometry:

Chlordiazepoxide: 10 ng/mL

Nordiazepam: 10 ng/mL

Oxazepam: 10 ng/mL

Interpretation

Combined concentrations of chlordiazepoxide and nordiazepam above 5000 ng/mL have been associated with toxicity.

Day(s) Performed

Wednesday

Report Available

2 to 7 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CDP Chlordiazepoxide and metabolites, S 33060-5

 

Result ID Test Result Name Result LOINC Value
8610 Chlordiazepoxide 3457-9
37321 Nordiazepam 3537-8
622870 Oxazepam 3886-9

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Neurology Specialty Testing Client Test Request (T732)

-Therapeutics Test Request (T831)