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HelpTest Code Billings Clinic: 9156 Mayo: AB2GP Beta-2 Glycoprotein 1 Antibodies, IgA, Serum
Reporting Name
Beta 2 GP1 Ab IgA, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Evaluating patients with suspected antiphospholipid syndrome by identification of beta-2 glycoprotein 1 IgA antibodies
Evaluating patients at-risk for antiphospholipid syndrome (APS) who are negative for criteria APS tests
Estimating the risk of thrombosis and/or pregnancy-related morbidity in patients with systemic lupus erythematosus
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 21 days | |
| Frozen | 21 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
| Heat-treated specimen | Reject |
Reference Values
<15.0 SAU (negative)
15.0-39.9 SAU (weakly positive)
40.0-79.9 SAU (positive)
≥80.0 SAU (strongly positive)
Results are reported in standard IgA anti-beta 2 glycoprotein 1 units (SAU).
Reference values apply to all ages.
Interpretation
The presence of anti-beta-2 glycoprotein 1 (anti-B2GPI) IgA antibodies may be associated with a diagnosis of antiphospholipid syndrome (APS) or systemic lupus erythematosus (SLE). In the absence of "criteria" aPL antibodies for APS and diagnostic tests for SLE, isolated anti-B2GPI IgA must be interpreted with a high degree of caution.
Documentation of persistence for anti-B2GPI IgA, as is the case for criteria B2GPI IgG and IgM antibodies, would be consistent with best clinical practice.
Detection of B2GPI antibodies is not affected by anticoagulant treatment.
Day(s) Performed
Monday, Wednesday, Friday
Report Available
4 to 6 daysTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86146
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| AB2GP | Beta 2 GP1 Ab IgA, S | 44447-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| AB2GP | Beta 2 GP1 Ab IgA, S | 44447-1 |