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HelpTest Code Billings Clinic: 9498 Quest: 16374 Streptococcus pneumoniae Antibody (IgG) (13 Serotypes), MAID
Performing Laboratory
Quest Diagnostics
Useful For
This test looks for Serotypes: 1, 3, 4, 5, 6 (6A), 14, 19 (19F), 23 (23F), 26 (6B), 51 (7F), 56 (18C), 57 (19A), 68 (9V)
There are 2 principal reasons to measure pneumococcal IgG antibodies:
- Estimate pre-existing antibody levels for different pneumococcal serotypes
- Assess immunologic responses after pneumococcal vaccination
Serologic correlates of protection against pneumococcal disease have not been rigorously established for all patient populations. Published data and expert consensus (including WHO) suggest protection from invasive disease usually occurs at levels ≥0.3-0.50 µg/mL for healthy children receiving pneumococcal conjugate vaccination. Higher titers may be necessary to protect from noninvasive infection (eg, pneumonia, otitis, sinusitis). Expert opinion suggests that a cut-off of ≥ 1.3 µg/mL may be a more relevant value to assess antibody responses after pneumococcal polysaccharide vaccines and for immunocompromised patients. In addition to antibody quantity, protection also depends on antibody avidity and opsonophagocytic activity.
Responses to pneumococcal conjugate vaccines are demonstrated by 2- to 4-fold increases in type-specific IgG levels.
Methodology
Multi-Analyte Immunodetection (MAID)
This test was developed and its analytical performance
characteristics have been determined by Quest Diagnostics. It has
not been cleared or approved by FDA. This assay has been validated
pursuant to the CLIA regulations and is used for clinical
purposes.
Specimen Requirements
- Draw blood in a Red-top or red-top gel tube(s).
- Spin down and send 0.5 mL of serum room temperature.
If you are interested in PRE and POST vaccination testing, please follow these instructions: PRE and POST samples should be tested together on the same run to avoid variation in results caused by lot to lot and inter assay variation. It is recommended that two PRE tubes be drawn. Save one PRE serum frozen. The other can be sent to determine the need to vaccinate. If patient already has protective values, there is no need to revaccinate and test a POST sample. If PRE results do not show protective values, send the saved PRE sample together with the POST vaccination sample.
Storage/Stability
| Specimen Type | Temperature | Time |
| Serum | Ambient (preferred) | 7 days |
| Refrigerated | 14 days | |
| Frozen | 3 months |
Reference Values
See Laboratory Report
Day(s) Test Set Up
Set up: Monday - Saturday
Report available: 2-5 days
Test Classification and CPT Coding
86317 (x13) - Immunoassay for infectious agent antibody, quantitative, not otherwise specified
LOINC Code Information
| LOINC Code | Reporting Name |
| 85954-6 | Streptococcus pneumoniae Danish serotype 1 Ab.IgG |
| 86080-9 | Streptococcus pneumoniae Danish serotype 3 Ab.IgG |
| 85991-8 | Streptococcus pneumoniae Danish serotype 14 Ab.IgG |
| 86024-7 | Streptococcus pneumoniae Danish serotype 19F Ab.IgG |
| 86064-3 | Streptococcus pneumoniae Danish serotype 23F Ab.IgG |
| 25296-5 | Streptococcus pneumoniae Danish serotype 7F Ab.IgG |
| 86107-0 | Streptococcus pneumoniae Danish serotype 4 Ab.IgG |
| 27118-9 | Streptococcus pneumoniae Danish serotype 6B Ab.IgG |
| 27395-3 | Streptococcus pneumoniae Danish serotype 18C Ab.IgG |
| 30153-1 | Streptococcus pneumoniae Danish serotype 9V Ab.IgG |
| 86130-2 | Streptococcus pneumoniae Danish serotype 5 Ab.IgG |
| 40974-8 | Streptococcus pneumoniae Danish serotype 19A Ab.IgG |
| 86136-9 | Streptococcus pneumoniae Danish serotype 6A Ab.IgG |