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Test Code Billings Clinic: 9565 Mayo: BHYD Beta-Hydroxybutyrate, Serum

Reporting Name

Beta-Hydroxybutyrate, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring therapy for diabetic ketoacidosis

 

Investigating the differential diagnosis of any patient presenting to the emergency room with hypoglycemia, acidosis, suspected alcohol ingestion, or an unexplained increase in the anion gap

 

In pediatric patients, the presence or absence of ketonemia/uria is an essential component in the differential diagnosis of inborn errors of metabolism

 

Serum beta-hydroxybutyrate is a key parameter monitored during controlled 24-hour fasts

Method Name

Photometric, B-Hydroxybutyrate Dehydrogenase (B-HBDH)


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged, and the serum aliquoted into a plastic vial within 2 hours of collection.


Specimen Type

Serum

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 7 days
  Refrigerated  7 days

Reject Due To

Gross hemolysis Reject

Reference Values

<0.4 mmol/L

Interpretation

The beta-hydroxybutyrate (BHB)/acetoacetate ratio is typically between 3:1 and 7:1 in severe ketotic states.

 

Serum BHB increases in response to fasting, but should not exceed 0.4 mmol/L following an overnight fast (up to 12 hours).

 

In pediatric patients, a hypo- or hyper-ketotic state (with or without hypoglycemia) may suggest specific groups of metabolic disorders.

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82010

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BHYD Beta-Hydroxybutyrate, S 6873-4

 

Result ID Test Result Name Result LOINC Value
BHYD Beta-Hydroxybutyrate, S 6873-4