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Test Code C7FX C7 Complement, Functional, Serum

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Method Name

Automated Liposome Lysis Assay

Reporting Name

C7 Complement, Functional, S


Advisory Information


The total complement (CH50) assay (COM / Complement, Total, Serum) assay should be used as a screen for suspected complement deficiencies before ordering individual complement component assays. A deficiency of an individual component of the complement cascade will result in an undetectable total complement level.

Specimen Required


Patient Preparation: Fasting preferred

Supplies: Aliquot Tube, 5 mL (T465)

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Immediately after specimen collection, place the tube on wet ice.

2. Centrifuge and aliquot serum into plastic vial.

3. Immediately freeze specimen.


Specimen Type

Serum Red

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Frozen 14 days

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK

Reference Values

36-60 U/mL

Day(s) and Time(s) Performed

Monday through Friday; 3 p.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86161

LOINC Code Information

Test ID Test Order Name Order LOINC Value
C7FX C7 Complement, Functional, S 87724-1

 

Result ID Test Result Name Result LOINC Value
C7FX C7 Complement, Functional, S 87724-1

Useful For

Diagnosis of C7 deficiency

 

Investigation of a patient with an undetectable total complement (CH50) level

Interpretation

Low levels of complement may be due to inherited deficiencies, acquired deficiencies, or due to complement consumption (eg, as a consequence of infectious or autoimmune processes).

 

Absent component 7 (C7) levels in the presence of normal C3 and C4 values are consistent with a C7 deficiency. Absent C7 levels in the presence of low C3 and C4 values suggest complement consumption.